Human immunodeficiency virus [HIV] disease

AB1_HIV

AIDS: A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 B20-B24
Hospital discharge: ICD-9 0788A|0788B|0788C
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 B20-B24
Cause of death: ICD-9 0788A|0788B|0788C
Cause of death: ICD-8 $!$

575

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

575

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Check minimum number of events None

575

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AB1_HIV

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Human immunodeficiency virus [HIV] disease based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 575 140 435
Unadjusted prevalence (%) 0.16 0.07 0.28
Mean age at first event (years) 41.05 39.96 41.40

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.65 [1.56, 8.56] 2.8e-3 18
15 years 0.02 2.71 [1.00, 7.38] 5.1e-2 11
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: AB1_HIV – Human immunodeficiency virus [HIV] disease
GWS hits:

Survival analyses between endpoints

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before Human immunodeficiency virus [HIV] disease
after Human immunodeficiency virus [HIV] disease

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Drugs most likely to be purchased after Human immunodeficiency virus [HIV] disease