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Infections with a predominantly sexual mode of transmission

DOID EFO MESH SNOMED PheWeb

AB1_SEXUAL_TRANSMISSION

tabes dorsalis: A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 A50-A64
Hospital discharge: ICD-9 09[0-9]|0541|131|0781C
Hospital discharge: ICD-8 09[0-9]|131
Cause of death: ICD-10 A50-A64
Cause of death: ICD-9 09[0-9]|0541|131|0781C
Cause of death: ICD-8 09[0-9]|131

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints

10187

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AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Infections with a predominantly sexual mode of transmission based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

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Summary Statistics

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Key figures

All Female Male
Number of individuals 10187 7459 2728
Unadjusted prevalence (%) 2.86 3.76 1.73
Mean age at first event (years) 32.57 31.18 36.37

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.24 [1.74, 2.89] 4.4e-10 317
15 years 0.01 1.26 [0.95, 1.67] 1.2e-1 112
5 years 0.00 2.37 [1.52, 3.69] 1.4e-4 61
1 year 0.00 3.65 [2.00, 6.66] 2.4e-5 18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AB1_SEXUAL_TRANSMISSION – Infections with a predominantly sexual mode of transmission
GWS hits:

Survival analyses between endpoints

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Plot

before Infections with a predominantly sexual mode of transmission
after Infections with a predominantly sexual mode of transmission

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Drugs most likely to be purchased after Infections with a predominantly sexual mode of transmission

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