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Viral infections of the central nervous system

DOID EFO MESH SNOMED PheWeb

AB1_VIRAL_CNS

viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 A80-A89
Hospital discharge: ICD-9 04[5-9]|071|06[2-4]
Hospital discharge: ICD-8 04[0-3]|06[2-5]|071
Cause of death: ICD-10 A80-A89
Cause of death: ICD-9 04[5-9]|071|06[2-4]
Cause of death: ICD-8 04[0-3]|06[2-5]|071

2119

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1750

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Check minimum number of events None

1750

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Include endpoints

1996

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AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Viral infections of the central nervous system based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 1996 1206 790
Unadjusted prevalence (%) 0.56 0.61 0.50
Mean age at first event (years) 38.57 37.28 40.54

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.35 [1.35, 4.08] 2.4e-3 210
15 years 0.01 1.28 [0.79, 2.08] 3.1e-1 62
5 years 0.00 3.69 [2.42, 5.61] 1.1e-9 47
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AB1_VIRAL_CNS – Viral infections of the central nervous system
GWS hits:

Survival analyses between endpoints

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Plot

before Viral infections of the central nervous system
after Viral infections of the central nervous system

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Drugs most likely to be purchased after Viral infections of the central nervous system

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