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Acute myeloid leukaemia

DOID EFO MESH SNOMED PheWeb

C3_AML

acute myeloid leukemia: Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

HLP_C3_AML

222

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Filter registries

Cause of death: ICD-10 C92.0
Cause of death: ICD-9 2050A
Cause of death: ICD-8 20500
Cancer registry: Topography ICD-O-3 ANY
Cancer registry: Morphology ICD-O-3 9840|9861|986[67]|987[1-4]|989[1567]|9910|9920|993[01]
Cancer registry: Behaviour codes 3

222

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

222

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Check minimum number of events None

222

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Include endpoints

222

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C3_AML

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 222 89 133
Unadjusted prevalence (%) 0.06 0.04 0.08
Mean age at first event (years) 59.23 52.23 63.92

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_AML – Acute myeloid leukaemia
GWS hits:

Survival analyses between endpoints

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Plot

before Acute myeloid leukaemia
after Acute myeloid leukaemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Acute myeloid leukaemia

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