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Chronic myeloid leukaemia

DOID EFO MESH PheWeb

C3_CML

obsolete_chronic myeloid leukemia: ['Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.']

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Cause of death: ICD-10 C92.1
Cause of death: ICD-9 2051A
Cause of death: ICD-8 20515
Cancer registry: Topography ICD-O-3 ANY
Cancer registry: Morphology ICD-O-3 9863|9875
Cancer registry: Behaviour codes 3

70416

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

99

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Check minimum number of events None

99

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Include endpoints None

99

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C3_CML

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 99 46 53
Unadjusted prevalence (%) 0.03 0.02 0.03
Mean age at first event (years) 55.92 54.52 57.13

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_CML – Chronic myeloid leukaemia
GWS hits:

Survival analyses between endpoints

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Plot

before Chronic myeloid leukaemia
after Chronic myeloid leukaemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Chronic myeloid leukaemia

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