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Colon adenocarcinoma

DOID EFO MESH PheWeb

C3_COLON_ADENO

colon adenocarcinoma: An adenocarcinoma arising from the colon. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

HLP_C3_COLON_ADENO

2609

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Filter registries

Cause of death: ICD-10 C18
Cause of death: ICD-9 153
Cause of death: ICD-8 153
Cancer registry: Topography ICD-O-3 C18
Cancer registry: Morphology ICD-O-3 8140
Cancer registry: Behaviour codes 3

2609

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

2609

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Check minimum number of events None

2609

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Include endpoints

2609

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C3_COLON_ADENO

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 2609 1091 1518
Unadjusted prevalence (%) 0.73 0.55 0.96
Mean age at first event (years) 67.74 66.06 68.95

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.55 [1.63, 3.99] 3.8e-5 870
15 years 0.01 0.94 [0.64, 1.39] 7.7e-1 212
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_COLON_ADENO – Colon adenocarcinoma
GWS hits:

Survival analyses between endpoints

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Plot

before Colon adenocarcinoma
after Colon adenocarcinoma

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Drugs most likely to be purchased after Colon adenocarcinoma

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