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Non-small cell lung cancer

DOID EFO MESH SNOMED PheWeb

C3_NSCLC

non-small cell lung carcinoma: A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Cause of death: ICD-10 C34
Cause of death: ICD-9 162
Cause of death: ICD-8 162
Cancer registry: Topography ICD-O-3 C34
Cancer registry: Morphology ICD-O-3 8046
Cancer registry: Behaviour codes 3

5285

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

3911

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Check minimum number of events None

3911

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Include endpoints

4805

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C3_NSCLC

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Similar endpoints

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List of similar endpoints to Non-small cell lung cancer based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 4805 833 3972
Unadjusted prevalence (%) 1.35 0.42 2.52
Mean age at first event (years) 71.94 68.87 72.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.51 39.60 [32.81, 47.81] <1e-100 3466
15 years 0.01 2.24 [1.76, 2.85] 7.5e-11 125
5 years 0.02 16.48 [13.63, 19.92] <1e-100 538
1 year 0.03 158.42 [141.69, 177.13] <1e-100 2792

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_NSCLC – Non-small cell lung cancer
GWS hits:

Survival analyses between endpoints

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Plot

before Non-small cell lung cancer
after Non-small cell lung cancer

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Drugs most likely to be purchased after Non-small cell lung cancer

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