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Anaemia due to enzyme disorders

DOID EFO MESH SNOMED PheWeb

D3_ANAEMIAENZYME

congenital nonspherocytic hemolytic anemia: Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte. In some cases, pyruvate kinase deficiency has been demonstrated; in other cases, glucose-6-phosphate dehydrogenase deficiency has been demonstrated.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D55
Hospital discharge: ICD-9 282[2-3]
Hospital discharge: ICD-8 282[2-3]
Cause of death: ICD-10 D55
Cause of death: ICD-9 282[2-3]
Cause of death: ICD-8 282[2-3]

28

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

28

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Check minimum number of events None

28

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Include endpoints None

28

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D3_ANAEMIAENZYME

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D55-D59
Name in latin Anaemiae ex perturbationibus enzymaticis

Summary Statistics

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Key figures

All Female Male
Number of individuals 28 16 12
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 46.95 40.70 55.30

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ANAEMIAENZYME – Anaemia due to enzyme disorders
GWS hits:

Survival analyses between endpoints

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Plot

before Anaemia due to enzyme disorders
after Anaemia due to enzyme disorders

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Drugs most likely to be purchased after Anaemia due to enzyme disorders

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