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Idiopathic thrombocytopenic purpura

DOID EFO MESH PheWeb

D3_ITP

autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D69.3
Hospital discharge: ICD-9 2873A
Hospital discharge: ICD-8 28710
Cause of death: ICD-10 D69.3
Cause of death: ICD-9 2873A
Cause of death: ICD-8 28710

732

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

732

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Check minimum number of events None

732

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Include endpoints None

732

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D3_ITP

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D69
Name in latin Purpura idiopathica thrombocytopenica

Similar endpoints

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List of similar endpoints to Idiopathic thrombocytopenic purpura based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 732 382 350
Unadjusted prevalence (%) 0.21 0.19 0.22
Mean age at first event (years) 48.67 43.47 54.35

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.13 8.14 [6.11, 10.84] 9.3e-47 123
15 years 0.02 3.02 [2.21, 4.14] 5.4e-12 39
5 years 0.01 6.16 [4.15, 9.14] 2.1e-19 33
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits:

Survival analyses between endpoints

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Plot

before Idiopathic thrombocytopenic purpura
after Idiopathic thrombocytopenic purpura

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Drugs most likely to be purchased after Idiopathic thrombocytopenic purpura

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