Idiopathic thrombocytopenic purpura

D3_ITP

autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D69.3
Hospital discharge: ICD-9 2873A
Hospital discharge: ICD-8 28710
Cause of death: ICD-10 D69.3
Cause of death: ICD-9 2873A
Cause of death: ICD-8 28710

732

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

732

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Check minimum number of events None

732

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Include endpoints None

732

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D3_ITP

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D69
Name in latin Purpura idiopathica thrombocytopenica

Similar endpoints

List of similar endpoints to Idiopathic thrombocytopenic purpura based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 732 382 350
Unadjusted prevalence (%) 0.21 0.19 0.22
Mean age at first event (years) 48.67 43.47 54.35

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.13 8.14 [6.11, 10.84] 9.3e-47 123
15 years 0.02 3.02 [2.21, 4.14] 5.4e-12 39
5 years 0.01 6.16 [4.15, 9.14] 2.1e-19 33
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits:

Survival analyses between endpoints

Plot

before Idiopathic thrombocytopenic purpura
after Idiopathic thrombocytopenic purpura

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Drugs most likely to be purchased after Idiopathic thrombocytopenic purpura