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MS-disease / Multiple Sclerosis

DOID EFO MESH SNOMED PheWeb

G6_MS

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G35
Hospital discharge: ICD-9 340
Hospital discharge: ICD-8 34099
Cause of death: ICD-10 G35
Cause of death: ICD-9 340
Cause of death: ICD-8 34099
KELA reimbursements: KELA codes 109

2019

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2009

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Check minimum number of events None

2009

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Include endpoints None

2009

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G6_MS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Sclerosis multiplex

Summary Statistics

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Key figures

All Female Male
Number of individuals 2009 1511 498
Unadjusted prevalence (%) 0.56 0.76 0.32
Mean age at first event (years) 39.45 38.37 42.71

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.25 [1.37, 3.68] 1.3e-3 86
15 years 0.01 1.77 [1.12, 2.80] 1.4e-2 40
5 years 0.00 2.91 [1.76, 4.80] 3.2e-5 19
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 2

Survival analyses between endpoints

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Plot

before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after MS-disease / Multiple Sclerosis

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