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Trigeminal neuralgia

DOID EFO MESH SNOMED PheWeb

G6_TRINEU

trigeminal neuralgia: Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G50.0
Hospital discharge: ICD-9 3501
Hospital discharge: ICD-8 35199
Cause of death: ICD-10 G50.0
Cause of death: ICD-9 3501
Cause of death: ICD-8 35199
KELA reimbursements: KELA codes 119

1484

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1484

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Check minimum number of events None

1484

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Include endpoints None

1484

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G6_TRINEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G50
Name in latin Neuralgia trigeminalis

Summary Statistics

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Key figures

All Female Male
Number of individuals 1484 1041 443
Unadjusted prevalence (%) 0.42 0.52 0.28
Mean age at first event (years) 54.18 52.55 57.99

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.00 [2.28, 3.93] 2.3e-15 142
15 years 0.01 1.78 [1.37, 2.32] 1.6e-5 69
5 years 0.00 2.12 [1.40, 3.22] 4.2e-4 28
1 year 0.00 5.71 [3.21, 10.16] 3.1e-9 14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_TRINEU – Trigeminal neuralgia
GWS hits:

Survival analyses between endpoints

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Plot

before Trigeminal neuralgia
after Trigeminal neuralgia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Trigeminal neuralgia

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