≡ Risteys
R8

Documentation Changelog GitHub Contact & Feedback

Disorders of lens

DOID EFO MESH SNOMED PheWeb

H7_LENS

cataract: Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)

Endpoint definition

↥
FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 H25-H28, H28.2*G71.11
Cause of death: ICD-10 H25-H28, H28.2*G71.11

55692

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

55692

diagram downward connector

Check minimum number of events None

55692

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

56930

diagram downward connector
H7_LENS

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 56930 29946 26984
Unadjusted prevalence (%) 16.00 15.09 17.15
Mean age at first event (years) 70.25 69.79 70.77

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.57 [2.34, 2.82] 1.6e-86 12067
15 years 0.01 1.58 [1.45, 1.72] 2.9e-27 5951
5 years 0.00 2.52 [2.35, 2.69] <1e-100 4118
1 year 0.00 3.13 [2.82, 3.48] 1.2e-97 1065

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: H7_LENS – Disorders of lens
GWS hits:

Survival analyses between endpoints

↥

Plot

before Disorders of lens
after Disorders of lens

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Disorders of lens

↥