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Cholesteatoma of middle ear

DOID EFO MESH SNOMED PheWeb

H8_CHOLEASTOMA

cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 H71
Hospital discharge: ICD-9 3853
Hospital discharge: ICD-8 38700
Cause of death: ICD-10 H71
Cause of death: ICD-9 3853
Cause of death: ICD-8 38700

1355

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1355

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Check minimum number of events None

1355

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Include endpoints None

1355

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H8_CHOLEASTOMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H65-H75
Name in latin Cholesteatoma auris mediae

Summary Statistics

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Key figures

All Female Male
Number of individuals 1355 596 759
Unadjusted prevalence (%) 0.38 0.30 0.48
Mean age at first event (years) 47.52 45.22 49.33

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 0.97 [0.59, 1.60] 9.1e-1 194
15 years 0.01 0.77 [0.50, 1.17] 2.1e-1 86
5 years 0.00 1.17 [0.76, 1.79] 4.7e-1 35
1 year 0.00 1.86 [0.96, 3.63] 6.8e-2 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits:

Survival analyses between endpoints

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Plot

before Cholesteatoma of middle ear
after Cholesteatoma of middle ear

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Drugs most likely to be purchased after Cholesteatoma of middle ear

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