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Ototoxic hearing loss

DOID EFO MESH PheWeb

H8_HL_OTOTOX

nonsyndromic deafness: An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 H91.0#
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H91.0#
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

44

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

44

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Check minimum number of events None

44

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Include endpoints None

44

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H8_HL_OTOTOX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H91
Name in latin Hypacusis ototoxica

Summary Statistics

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Key figures

All Female Male
Number of individuals 44 23 21
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 59.61 60.27 58.88

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_HL_OTOTOX – Ototoxic hearing loss
GWS hits:

Survival analyses between endpoints

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Plot

before Ototoxic hearing loss
after Ototoxic hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ototoxic hearing loss

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