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Personality disorders

DOID EFO MESH PheWeb

KRA_PSY_PERSON

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F60, F61
Hospital discharge: ICD-9 31[0|2|4]|315A|31[6-8]
Hospital discharge: ICD-8 30100|301[2-9]
Cause of death: ICD-10 F60, F61
Cause of death: ICD-9 31[0|2|4]|315A|31[6-8]
Cause of death: ICD-8 30100|301[2-9]

10416

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

9441

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Check minimum number of events None

9441

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Include endpoints None

9441

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KRA_PSY_PERSON

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 9441 5917 3524
Unadjusted prevalence (%) 2.65 2.98 2.24
Mean age at first event (years) 34.76 34.76 34.77

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.33 [1.71, 3.18] 7.6e-8 501
15 years 0.01 1.94 [1.48, 2.56] 2.2e-6 227
5 years 0.00 2.47 [1.80, 3.39] 2.3e-8 65
1 year 0.00 5.89 [3.84, 9.01] 3.6e-16 27

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: KRA_PSY_PERSON – Personality disorders
GWS hits:

Survival analyses between endpoints

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Plot

before Personality disorders
after Personality disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Personality disorders

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