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Linear scleroderma

DOID EFO MESH PheWeb

L12_LINEARSCLERODERMA

scleroderma: Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc) (see these terms).

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 L94.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 L94.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

24

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

24

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Include endpoints None

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L12_LINEARSCLERODERMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L94
Name in latin Scleroderma lineare

Summary Statistics

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Key figures

All Female Male
Number of individuals 24 17 7
Unadjusted prevalence (%) 0.01 0.01 0.00
Mean age at first event (years) 39.25 37.08 44.52

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_LINEARSCLERODERMA – Linear scleroderma
GWS hits:

Survival analyses between endpoints

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Plot

before Linear scleroderma
after Linear scleroderma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Linear scleroderma

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