Ankylosing spondylitis, strict definition

M13_ANKYLOSPON_STRICT

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

M13_ANKYLOSPON_ICD10

2461

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Filter registries

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M45

2255

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Check pre-conditions, main-only, mode, ICD version None

1112

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Check minimum number of events None

1112

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Include endpoints None

1112

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M13_ANKYLOSPON_STRICT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 1112 517 595
Unadjusted prevalence (%) 0.31 0.26 0.38
Mean age at first event (years) 40.53 39.64 41.31

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.73 [0.38, 1.38] 3.3e-1 19
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_ANKYLOSPON_STRICT – Ankylosing spondylitis, strict definition
GWS hits: 8

Survival analyses between endpoints

Plot

before Ankylosing spondylitis, strict definition
after Ankylosing spondylitis, strict definition

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Drugs most likely to be purchased after Ankylosing spondylitis, strict definition