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Myelofibrosis

DOID EFO MESH PheWeb

MYELOFIBROSIS

primary myelofibrosis: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 C94.5
Hospital discharge: ICD-9 2387A
Hospital discharge: ICD-8 209
Cause of death: ICD-10 C94.5
Cause of death: ICD-9 2387A
Cause of death: ICD-8 209

19

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

19

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Check minimum number of events None

19

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Include endpoints None

19

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MYELOFIBROSIS

Extra metadata

First used in FinnGen datafreeze DF2, additional

Summary Statistics

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Key figures

All Female Male
Number of individuals 19 6 13
Unadjusted prevalence (%) 0.01 0.00 0.01
Mean age at first event (years) 52.36 40.48 57.84

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: MYELOFIBROSIS – Myelofibrosis
GWS hits:

Survival analyses between endpoints

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Plot

before Myelofibrosis
after Myelofibrosis

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