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Nephrotic syndrome

DOID EFO MESH SNOMED PheWeb

N14_NEPHROTICSYND

nephrotic syndrome: A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 N04#
Hospital discharge: ICD-9 581
Hospital discharge: ICD-8 581
Cause of death: ICD-10 N04#
Cause of death: ICD-9 581
Cause of death: ICD-8 581

799

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

799

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Check minimum number of events None

799

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Include endpoints None

799

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N14_NEPHROTICSYND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N00-N08
Name in latin Syndroma nephroticum

Summary Statistics

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Key figures

All Female Male
Number of individuals 799 329 470
Unadjusted prevalence (%) 0.22 0.17 0.30
Mean age at first event (years) 44.06 39.78 47.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 6.54 [4.02, 10.65] 4.3e-14 115
15 years 0.02 3.34 [2.21, 5.03] 8.7e-9 43
5 years 0.01 9.43 [6.42, 13.84] 2.7e-30 45
1 year 0.00 14.38 [8.06, 25.66] 1.8e-19 15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: N14_NEPHROTICSYND – Nephrotic syndrome
GWS hits: 2

Survival analyses between endpoints

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Plot

before Nephrotic syndrome
after Nephrotic syndrome

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Drugs most likely to be purchased after Nephrotic syndrome

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