General symptoms and signs


No definition available.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 R50-R69
Cause of death: ICD-10 R50-R69


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


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Check minimum number of events None


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Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF4
Parent code in ICD-10 R
Name in latin Symptomata et signa generalia

Summary Statistics

Key figures

All Female Male
Number of individuals 88011 49726 38285
Unadjusted prevalence (%) 24.74 25.06 24.33
Mean age at first event (years) 52.46 49.02 56.93


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.09 [3.76, 4.44] <1e-100 12642
15 years 0.01 1.85 [1.70, 2.01] 1.7e-46 3822
5 years 0.01 4.69 [4.37, 5.02] <1e-100 4282
1 year 0.00 16.60 [15.15, 18.19] <1e-100 3679

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: R18_GENERAL_SYMPTOMS_SIGNS – General symptoms and signs
GWS hits:

Survival analyses between endpoints


before General symptoms and signs
after General symptoms and signs

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after General symptoms and signs