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Alcohol-induced chronic pancreatitis

DOID EFO MESH SNOMED PheWeb

ALCOPANCCHRON

alcoholic pancreatitis: Acute or chronic inflammation of the pancreas due to excessive alcohol drinking. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K86.00, K86.01, K86.08
Hospital discharge: ICD-9 5771C|5771D
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K86.00, K86.01, K86.08
Cause of death: ICD-9 5771C|5771D
Cause of death: ICD-8 $!$

1655

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1655

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Check minimum number of events None

1655

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Include endpoints None

1655

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ALCOPANCCHRON

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1655 362 1293
Unadjusted prevalence (%) 0.47 0.18 0.82
Mean age at first event (years) 50.78 49.07 51.26

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.88 [1.76, 4.71] 2.5e-5 322
15 years 0.01 2.00 [1.28, 3.11] 2.3e-3 145
5 years 0.00 2.77 [1.74, 4.41] 1.7e-5 57
1 year 0.00 17.72 [11.43, 27.47] 8.2e-38 65

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ALCOPANCCHRON – Alcohol-induced chronic pancreatitis
GWS hits: 5

Survival analyses between endpoints

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Plot

before Alcohol-induced chronic pancreatitis
after Alcohol-induced chronic pancreatitis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alcohol-induced chronic pancreatitis

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