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Atopic dermatitis, strict definition with reimbursement

DOID EFO MESH PheWeb

ATOPIC_STRICT_REIMB

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

KELA reimbursements: KELA codes 134|395|317

2054

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Check pre-conditions, main-only, mode, ICD version None

2054

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Check minimum number of events None

2054

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Include endpoints

9953

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ATOPIC_STRICT_REIMB

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 9953 6881 3072
Unadjusted prevalence (%) 2.80 3.47 1.95
Mean age at first event (years) 27.49 27.40 27.67

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.22 [1.66, 2.97] 7.8e-8 292
15 years 0.01 1.60 [1.22, 2.09] 6.1e-4 122
5 years 0.00 2.99 [2.23, 4.01] 2.0e-13 63
1 year 0.00 4.79 [2.96, 7.74] 1.6e-10 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ATOPIC_STRICT_REIMB – Atopic dermatitis, strict definition with reimbursement
GWS hits:

Survival analyses between endpoints

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Plot

before Atopic dermatitis, strict definition with reimbursement
after Atopic dermatitis, strict definition with reimbursement

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Drugs most likely to be purchased after Atopic dermatitis, strict definition with reimbursement

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