Atopic dermatitis, strict definition


atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 L20.0
Hospital discharge: ICD-9 6918B
Hospital discharge: ICD-8 69100
Cause of death: ICD-10 L20.0
Cause of death: ICD-9 6918B
Cause of death: ICD-8 69100


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 L20
Name in latin Eczema atopicum

Summary Statistics

Key figures

All Female Male
Number of individuals 9377 6577 2800
Unadjusted prevalence (%) 2.64 3.31 1.78
Mean age at first event (years) 26.52 26.83 25.79


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.39 [0.93, 2.08] 1.0e-1 229
15 years 0.01 0.99 [0.65, 1.50] 9.6e-1 92
5 years 0.00 2.12 [1.42, 3.16] 2.2e-4 49
1 year 0.00 3.32 [1.83, 6.01] 7.3e-5 14

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: ATOPIC_STRICT – Atopic dermatitis, strict definition
GWS hits:

Survival analyses between endpoints


before Atopic dermatitis, strict definition
after Atopic dermatitis, strict definition

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Drugs most likely to be purchased after Atopic dermatitis, strict definition