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Malignant neoplasm of breast, HER2-negative

PheWeb

C3_BREAST_HER2NEG

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule

Sex only females

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Check conditions

not RX_HER2PLUS

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Filter registries

Cause of death: ICD-10 C50
Cause of death: ICD-9 174
Cause of death: ICD-8 174
Cancer registry: Topography ICD-O-3 C50

13181

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

13181

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Check minimum number of events None

13181

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Include endpoints None

13181

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C3_BREAST_HER2NEG

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF5

Summary Statistics

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Key figures

All Female Male
Number of individuals 13181 13181 -
Unadjusted prevalence (%) 3.70 6.64 -
Mean age at first event (years) 58.15 58.15 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.15 [0.89, 1.48] 3.0e-1 1334
15 years 0.01 0.84 [0.68, 1.04] 1.1e-1 594
5 years 0.00 1.85 [1.53, 2.23] 1.7e-10 393
1 year 0.00 2.63 [2.04, 3.39] 1.2e-13 102

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_BREAST_HER2NEG – Malignant neoplasm of breast, HER2-negative
GWS hits:

Survival analyses between endpoints

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Plot

before Malignant neoplasm of breast, HER2-negative
after Malignant neoplasm of breast, HER2-negative

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Malignant neoplasm of breast, HER2-negative

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