≡ Risteys
R8

Documentation Changelog GitHub Contact & Feedback

Diffuse large B-cell lymphoma

DOID EFO MESH PheWeb

C3_DLBCL

diffuse large B-cell lymphoma: Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.

Endpoint definition

↥
FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector
diagram bullet

Check conditions

HLP_C3_DLBCL

797

diagram downward connector
diagram bullet

Filter registries

Cause of death: ICD-10 C83.3
Cause of death: ICD-9 2000B
Cancer registry: Topography ICD-O-3 ANY
Cancer registry: Morphology ICD-O-3 9680
Cancer registry: Behaviour codes 3

797

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 9

797

diagram downward connector

Check minimum number of events None

797

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

797

diagram downward connector
C3_DLBCL

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 797 340 457
Unadjusted prevalence (%) 0.22 0.17 0.29
Mean age at first event (years) 65.58 63.76 66.93

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.88 [2.54, 13.62] 3.6e-5 228
15 years 0.01 1.32 [0.54, 3.22] 5.5e-1 39
5 years 0.01 8.34 [4.54, 15.30] 7.8e-12 76
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: C3_DLBCL – Diffuse large B-cell lymphoma
GWS hits:

Survival analyses between endpoints

↥

Plot

before Diffuse large B-cell lymphoma
after Diffuse large B-cell lymphoma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diffuse large B-cell lymphoma

↥