Diffuse large B-cell lymphoma

C3_DLBCL

diffuse large B-cell lymphoma: Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

HLP_C3_DLBCL

797

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Filter registries

Cause of death: ICD-10 C83.3
Cause of death: ICD-9 2000B
Cancer registry: Topography ICD-O-3 ANY
Cancer registry: Morphology ICD-O-3 9680
Cancer registry: Behaviour codes 3

797

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 9

797

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Check minimum number of events None

797

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Include endpoints

797

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C3_DLBCL

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

Key figures

All Female Male
Number of individuals 797 340 457
Unadjusted prevalence (%) 0.22 0.17 0.29
Mean age at first event (years) 65.58 63.76 66.93

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.88 [2.54, 13.62] 3.6e-5 228
15 years 0.01 1.32 [0.54, 3.22] 5.5e-1 39
5 years 0.01 8.34 [4.54, 15.30] 7.8e-12 76
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: C3_DLBCL – Diffuse large B-cell lymphoma
GWS hits:

Survival analyses between endpoints

Plot

before Diffuse large B-cell lymphoma
after Diffuse large B-cell lymphoma

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Drugs most likely to be purchased after Diffuse large B-cell lymphoma