Non-small cell lung cancer

C3_LUNG_NONSMALL

non-small cell lung carcinoma: A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 C34.[123457]
Cause of death: ICD-10 C34.[123457]

3998

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

3998

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Check minimum number of events None

3998

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Include endpoints None

3998

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C3_LUNG_NONSMALL

Extra metadata

First used in FinnGen datafreeze DF4

Summary Statistics

Key figures

All Female Male
Number of individuals 3998 1194 2804
Unadjusted prevalence (%) 1.12 0.60 1.78
Mean age at first event (years) 70.34 67.32 71.63

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.37 27.37 [21.78, 34.38] <1e-100 2116
15 years 0.01 1.98 [1.53, 2.55] 1.6e-7 121
5 years 0.02 15.71 [12.63, 19.54] <1e-100 646
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: C3_LUNG_NONSMALL – Non-small cell lung cancer
GWS hits:

Survival analyses between endpoints

Plot

before Non-small cell lung cancer
after Non-small cell lung cancer

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Drugs most likely to be purchased after Non-small cell lung cancer