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Follicular lymphoma

DOID EFO MESH SNOMED PheWeb

CD2_FOLLICULAR_LYMPHOMA

neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 C82
Hospital discharge: ICD-9 2000A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 C82
Cause of death: ICD-9 2000A
Cause of death: ICD-8 $!$

986

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

986

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Check minimum number of events None

986

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Include endpoints None

986

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CD2_FOLLICULAR_LYMPHOMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 C81-C96
Name in latin Lymphoma non-Hodgkin nodulare (folliculare)

Summary Statistics

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Key figures

All Female Male
Number of individuals 986 494 492
Unadjusted prevalence (%) 0.28 0.25 0.31
Mean age at first event (years) 61.87 60.54 63.22

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.97 [0.91, 4.24] 8.5e-2 159
15 years 0.01 0.99 [0.52, 1.90] 9.8e-1 53
5 years 0.00 3.29 [1.91, 5.67] 1.7e-5 60
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CD2_FOLLICULAR_LYMPHOMA – Follicular lymphoma
GWS hits:

Survival analyses between endpoints

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Plot

before Follicular lymphoma
after Follicular lymphoma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Follicular lymphoma

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