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Hodgkin lymphoma

DOID EFO MESH PheWeb

CD2_HODGKIN_LYMPHOMA

non-Hodgkins lymphoma: Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 C81
Hospital discharge: ICD-9 201
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 C81
Cause of death: ICD-9 201
Cause of death: ICD-8 $!$

761

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

720

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Check minimum number of events None

720

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Include endpoints None

720

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CD2_HODGKIN_LYMPHOMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 C81-C96
Name in latin Morbus Hodgkin

Summary Statistics

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Key figures

All Female Male
Number of individuals 720 345 375
Unadjusted prevalence (%) 0.20 0.17 0.24
Mean age at first event (years) 47.33 42.55 51.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.12 7.34 [4.21, 12.78] 1.9e-12 114
15 years 0.03 3.70 [2.44, 5.62] 7.4e-10 45
5 years 0.01 6.84 [4.10, 11.40] 1.7e-13 32
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CD2_HODGKIN_LYMPHOMA – Hodgkin lymphoma
GWS hits:

Survival analyses between endpoints

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Plot

before Hodgkin lymphoma
after Hodgkin lymphoma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hodgkin lymphoma

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