≡ Risteys
R8

Documentation Changelog GitHub Contact & Feedback

Carcinoma in situ of breast

DOID EFO MESH PheWeb

CD2_INSITU_BREAST

breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.

Endpoint definition

↥
FinnGen phenotype data

356077 individuals

diagram downward connector
diagram bullet

Apply sex-specific rule

Sex only females

198506

diagram downward connector

Check conditions None

198506

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 D05
Cause of death: ICD-10 D05

2230

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

2230

diagram downward connector

Check minimum number of events None

2230

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

2260

diagram downward connector
CD2_INSITU_BREAST

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D00-D09
Name in latin Carcinoma in situ mammae

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 2260 2260 -
Unadjusted prevalence (%) 0.64 1.14 -
Mean age at first event (years) 59.41 59.41 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.14 [0.51, 2.59] 7.4e-1 89
15 years 0.01 0.99 [0.53, 1.86] 9.8e-1 48
5 years 0.00 1.55 [0.86, 2.82] 1.5e-1 22
1 year 0.00 3.76 [1.82, 7.78] 3.6e-4 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: CD2_INSITU_BREAST – Carcinoma in situ of breast
GWS hits:

Survival analyses between endpoints

↥

Plot

before Carcinoma in situ of breast
after Carcinoma in situ of breast

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Carcinoma in situ of breast

↥