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Carcinoma in situ of breast, intraductal

DOID EFO MESH PheWeb

CD2_INSITU_BREAST_INTRADUCTAL

breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule

Sex only females

198506

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Check conditions None

198506

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Filter registries

Hospital Discharge: ICD-10 D05.1&
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 D05.1&
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

2041

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2041

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Check minimum number of events None

2041

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Include endpoints None

2041

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CD2_INSITU_BREAST_INTRADUCTAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D05
Name in latin Carcinoma in situ intraductale mammae

Summary Statistics

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Key figures

All Female Male
Number of individuals 2041 2041 -
Unadjusted prevalence (%) 0.57 1.03 -
Mean age at first event (years) 59.73 59.73 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.76 [0.38, 1.52] 4.4e-1 74
15 years 0.01 0.67 [0.36, 1.24] 2.0e-1 40
5 years 0.00 1.36 [0.77, 2.40] 2.9e-1 23
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CD2_INSITU_BREAST_INTRADUCTAL – Carcinoma in situ of breast, intraductal
GWS hits:

Survival analyses between endpoints

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Plot

before Carcinoma in situ of breast, intraductal
after Carcinoma in situ of breast, intraductal

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Drugs most likely to be purchased after Carcinoma in situ of breast, intraductal

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