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Primary biliary cholangitis (PBC)

DOID EFO MESH SNOMED PheWeb

CHIRBIL_PRIM

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K74.3
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K74.3
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

515

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

515

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Check minimum number of events None

515

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Include endpoints None

515

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CHIRBIL_PRIM

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K74
Name in latin Cirrhosis biliaris [primaria]

Summary Statistics

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Key figures

All Female Male
Number of individuals 515 422 93
Unadjusted prevalence (%) 0.14 0.21 0.06
Mean age at first event (years) 56.18 55.28 60.26

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.56 [1.32, 4.98] 5.4e-3 56
15 years 0.01 1.75 [0.90, 3.40] 9.9e-2 21
5 years 0.01 4.65 [2.59, 8.37] 2.8e-7 16
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CHIRBIL_PRIM – Primary biliary cholangitis (PBC)
GWS hits:

Survival analyses between endpoints

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Plot

before Primary biliary cholangitis (PBC)
after Primary biliary cholangitis (PBC)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Primary biliary cholangitis (PBC)

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