Cryoglobulinemia

D3_CRYOGLOBU

cryoglobulinemia: Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease ); and/or cancers of the blood or immune system . Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D89.1
Hospital discharge: ICD-9 2732A
Hospital discharge: ICD-8 2754
Cause of death: ICD-10 D89.1
Cause of death: ICD-9 2732A
Cause of death: ICD-8 2754

74

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

35

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Check minimum number of events None

35

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Include endpoints None

35

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D3_CRYOGLOBU

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D89
Name in latin Cryoglobulinaemia

Summary Statistics

Key figures

All Female Male
Number of individuals 35 16 19
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 51.80 52.00 51.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_CRYOGLOBU – Cryoglobulinemia
GWS hits:

Survival analyses between endpoints

Plot

before Cryoglobulinemia
after Cryoglobulinemia

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Drugs most likely to be purchased after Cryoglobulinemia