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Hyperimmunoglobulin E [IgE] syndrome

DOID EFO MESH PheWeb

D3_HYPERIGESDR

obsolete_Job's syndrome: ['Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.']

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D82.4
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 D82.4
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

15

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

15

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Check minimum number of events None

15

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Include endpoints None

15

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D3_HYPERIGESDR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D82
Name in latin Syndroma hyperimmunoglobulini E (IgE)

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 15 10 5
Unadjusted prevalence (%) 0.00 0.01 0.00
Mean age at first event (years) 40.44 38.31 44.71

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_HYPERIGESDR – Hyperimmunoglobulin E [IgE] syndrome
GWS hits:

Survival analyses between endpoints

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Plot

before Hyperimmunoglobulin E [IgE] syndrome
after Hyperimmunoglobulin E [IgE] syndrome

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hyperimmunoglobulin E [IgE] syndrome

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