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Sarcoidosis

DOID EFO MESH PheWeb

D3_SARCOIDOSIS

obsolete_sarcoidosis: ['An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.', 'An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.']

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D86
Hospital discharge: ICD-9 135
Hospital discharge: ICD-8 135
Cause of death: ICD-10 D86
Cause of death: ICD-9 135
Cause of death: ICD-8 135
KELA reimbursements: KELA codes 132

3687

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3687

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Check minimum number of events None

3687

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Include endpoints None

3687

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D3_SARCOIDOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D80-D89
Name in latin Sarcoidosis

Summary Statistics

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Key figures

All Female Male
Number of individuals 3687 2047 1640
Unadjusted prevalence (%) 1.04 1.03 1.04
Mean age at first event (years) 46.91 47.47 46.22

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.10 [0.73, 1.65] 6.6e-1 293
15 years 0.01 0.82 [0.57, 1.18] 2.9e-1 114
5 years 0.00 1.48 [1.01, 2.16] 4.3e-2 50
1 year 0.00 4.29 [2.70, 6.80] 6.3e-10 26

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_SARCOIDOSIS – Sarcoidosis
GWS hits: 11

Survival analyses between endpoints

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Plot

before Sarcoidosis
after Sarcoidosis

loading spinner Loading survival analyses plot