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Other diabetes, wide definition

DOID EFO MESH SNOMED PheWeb

DM_OTHER_WIDE

Takayasu arteritis: Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis primarily affecting the aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not GEST_DIABETES

344194

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Filter registries

Hospital Discharge: ICD-10 E13
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E13
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

1108

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

957

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Check minimum number of events None

957

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Include endpoints

53217

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DM_OTHER_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 53217 22179 31038
Unadjusted prevalence (%) 14.96 11.18 19.72
Mean age at first event (years) 56.55 55.94 56.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.25 [2.04, 2.48] 1.6e-59 9127
15 years 0.01 1.67 [1.53, 1.81] 3.7e-34 4853
5 years 0.00 2.32 [2.16, 2.51] <1e-100 2155
1 year 0.00 2.03 [1.77, 2.33] 3.8e-24 354

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_OTHER_WIDE – Other diabetes, wide definition
GWS hits:

Survival analyses between endpoints

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Plot

before Other diabetes, wide definition
after Other diabetes, wide definition

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Drugs most likely to be purchased after Other diabetes, wide definition

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