Diabetes, varying definitions

DIABETES_FG

diabetes mellitus: A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

Endpoint definition

FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector

Filter registries None

0

diagram downward connector

Check pre-conditions, main-only, mode, ICD version None

0

diagram downward connector

Check minimum number of events None

0

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

60969

diagram downward connector
DIABETES_FG

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 60969 26979 33990
Unadjusted prevalence (%) 17.14 13.60 21.60
Mean age at first event (years) 54.97 53.00 56.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.41 [2.20, 2.65] 9.6e-77 10469
15 years 0.01 1.72 [1.59, 1.86] 3.5e-42 5205
5 years 0.00 2.52 [2.34, 2.70] <1e-100 2447
1 year 0.00 4.72 [4.22, 5.28] <1e-100 872

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: DIABETES_FG – Diabetes, varying definitions
GWS hits:

Survival analyses between endpoints

Plot

before Diabetes, varying definitions
after Diabetes, varying definitions

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetes, varying definitions