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Adrenocortical insufficiency

DOID MESH PheWeb

E4_ADDISON

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E27.1, E27.2, E27.3#, E27.4
Hospital discharge: ICD-9 2554
Hospital discharge: ICD-8 2551
Cause of death: ICD-10 E27.1, E27.2, E27.3#, E27.4
Cause of death: ICD-9 2554
Cause of death: ICD-8 2551
KELA reimbursements: KELA codes 105

851

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

820

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Check minimum number of events None

820

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Include endpoints None

820

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E4_ADDISON

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 820 541 279
Unadjusted prevalence (%) 0.23 0.27 0.18
Mean age at first event (years) 50.01 48.58 52.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.52 [2.44, 8.36] 1.5e-6 104
15 years 0.01 1.86 [1.05, 3.29] 3.4e-2 32
5 years 0.01 7.23 [4.19, 12.47] 1.1e-12 36
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_ADDISON – Adrenocortical insufficiency
GWS hits: 2

Survival analyses between endpoints

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Plot

before Adrenocortical insufficiency
after Adrenocortical insufficiency

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Adrenocortical insufficiency

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