≡ Risteys
R8

Documentation Changelog GitHub Contact & Feedback

Hypopituitarism

DOID EFO MESH SNOMED PheWeb

E4_HYPOPIT

hypopituitarism: A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

Endpoint definition

↥
FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Hospital discharge: ICD-9 2532
Hospital discharge: ICD-8 2531
Cause of death: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Cause of death: ICD-9 2532
Cause of death: ICD-8 2531
KELA reimbursements: KELA codes 101

1736

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1701

diagram downward connector

Check minimum number of events None

1701

diagram downward connector

Include endpoints None

1701

diagram downward connector
E4_HYPOPIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 1701 617 1084
Unadjusted prevalence (%) 0.48 0.31 0.69
Mean age at first event (years) 43.10 41.32 44.11

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.98 [1.07, 3.67] 3.0e-2 110
15 years 0.01 1.03 [0.57, 1.86] 9.2e-1 40
5 years 0.00 2.21 [1.21, 4.04] 9.7e-3 30
1 year 0.00 7.87 [4.12, 15.03] 4.3e-10 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: E4_HYPOPIT – Hypopituitarism
GWS hits:

Survival analyses between endpoints

↥

Plot

before Hypopituitarism
after Hypopituitarism

loading spinner Loading survival analyses plot