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Other metabolic disorders

DOID EFO MESH SNOMED PheWeb

E4_METABO

metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E88
Cause of death: ICD-10 E88

7771

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

285

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Check minimum number of events None

285

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Include endpoints

3377

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E4_METABO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E70-E90
Name in latin Aliae morbositates metabolicae

Similar endpoints

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List of similar endpoints to Other metabolic disorders based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 3377 2626 751
Unadjusted prevalence (%) 0.95 1.32 0.48
Mean age at first event (years) 51.54 51.06 53.21

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.28 [2.10, 5.12] 1.7e-7 200
15 years 0.01 1.59 [1.08, 2.35] 2.0e-2 75
5 years 0.00 3.37 [2.14, 5.31] 1.8e-7 64
1 year 0.00 9.23 [5.58, 15.29] 5.5e-18 33

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_METABO – Other metabolic disorders
GWS hits:

Survival analyses between endpoints

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Plot

before Other metabolic disorders
after Other metabolic disorders

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Drugs most likely to be purchased after Other metabolic disorders

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