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Metabolic disorders

DOID EFO MESH SNOMED PheWeb

E4_METABOLIA

metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E70-E90
Cause of death: ICD-10 E70-E90

62423

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

46459

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Check minimum number of events None

46459

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Include endpoints

47689

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E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 47689 22731 24958
Unadjusted prevalence (%) 13.40 11.46 15.86
Mean age at first event (years) 62.48 61.46 63.41

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.41 [3.02, 3.84] 1.2e-90 7672
15 years 0.01 1.69 [1.52, 1.88] 1.4e-22 2759
5 years 0.00 3.82 [3.50, 4.16] <1e-100 2539
1 year 0.00 14.34 [12.95, 15.87] <1e-100 2024

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_METABOLIA – Metabolic disorders
GWS hits: 30

Survival analyses between endpoints

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Plot

before Metabolic disorders
after Metabolic disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Metabolic disorders

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