Autoimmune thyroiditis

E4_THYROIDITAUTOIM

autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.

Endpoint definition

FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 E06.3
Hospital discharge: ICD-9 2452
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E06.3
Cause of death: ICD-9 2452
Cause of death: ICD-8 $!$

445

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

445

diagram downward connector

Check minimum number of events None

445

diagram downward connector

Include endpoints None

445

diagram downward connector
E4_THYROIDITAUTOIM

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E06
Name in latin Thyreoiditis autoimmunis

Summary Statistics

Key figures

All Female Male
Number of individuals 445 376 69
Unadjusted prevalence (%) 0.13 0.19 0.04
Mean age at first event (years) 41.99 41.21 46.25

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.51 [0.48, 4.77] 4.8e-1 19
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis
GWS hits: 2

Survival analyses between endpoints

Plot

before Autoimmune thyroiditis
after Autoimmune thyroiditis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Autoimmune thyroiditis