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Disorders of the thyroid gland

DOID EFO MESH PheWeb

E4_THYROID

thyroid nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E00-E07
Cause of death: ICD-10 E00-E07

25814

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

25791

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Check minimum number of events None

25791

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Include endpoints

51847

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E4_THYROID

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 51847 41061 10786
Unadjusted prevalence (%) 14.57 20.70 6.85
Mean age at first event (years) 51.14 49.41 57.71

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.54 [1.37, 1.73] 5.3e-13 4000
15 years 0.01 1.09 [0.99, 1.21] 9.1e-2 1894
5 years 0.00 1.93 [1.74, 2.13] 1.2e-37 955
1 year 0.00 2.30 [1.94, 2.72] 2.1e-22 207

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYROID – Disorders of the thyroid gland
GWS hits: 97

Survival analyses between endpoints

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Plot

before Disorders of the thyroid gland
after Disorders of the thyroid gland

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Disorders of the thyroid gland

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