Thyrotoxicosis with toxic multinodular goitre

E4_THYTOXGOITMULT

Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E05.2
Hospital discharge: ICD-9 2422
Hospital discharge: ICD-8 2421
Cause of death: ICD-10 E05.2
Cause of death: ICD-9 2422
Cause of death: ICD-8 2421

1559

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1447

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Check minimum number of events None

1447

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Include endpoints None

1447

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E4_THYTOXGOITMULT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma multinodulari

Summary Statistics

Key figures

All Female Male
Number of individuals 1447 1170 277
Unadjusted prevalence (%) 0.41 0.59 0.18
Mean age at first event (years) 57.56 56.37 62.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.35 [0.70, 2.58] 3.7e-1 153
15 years 0.01 0.87 [0.51, 1.49] 6.2e-1 56
5 years 0.00 2.11 [1.34, 3.33] 1.3e-3 38
1 year 0.00 4.22 [2.29, 7.75] 3.7e-6 15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 12

Survival analyses between endpoints

Plot

before Thyrotoxicosis with toxic multinodular goitre
after Thyrotoxicosis with toxic multinodular goitre

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Drugs most likely to be purchased after Thyrotoxicosis with toxic multinodular goitre