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Thyrotoxicosis with toxic single thyroid nodule

DOID EFO MESH SNOMED PheWeb

E4_THYTOXNOD

Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E05.1
Hospital discharge: ICD-9 2421
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E05.1
Cause of death: ICD-9 2421
Cause of death: ICD-8 $!$

433

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

204

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Check minimum number of events None

204

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Include endpoints None

204

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E4_THYTOXNOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma uninodulari

Summary Statistics

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Key figures

All Female Male
Number of individuals 204 173 31
Unadjusted prevalence (%) 0.06 0.09 0.02
Mean age at first event (years) 51.47 49.22 64.02

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule
GWS hits: 1

Survival analyses between endpoints

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Plot

before Thyrotoxicosis with toxic single thyroid nodule
after Thyrotoxicosis with toxic single thyroid nodule

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Thyrotoxicosis with toxic single thyroid nodule

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