unipolar depression: A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 F32, F33
Hospital discharge: ICD-9 2961|2968|3004
Cause of death: ICD-10 F32, F33
Cause of death: ICD-9 2961|2968|3004


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 9 ; C.O.D: 10, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF8

Summary Statistics

Key figures

All Female Male
Number of individuals 39747 26599 13148
Unadjusted prevalence (%) 11.17 13.41 8.35
Mean age at first event (years) 41.73 40.25 44.74


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.83 [2.36, 3.39] 8.2e-30 2700
15 years 0.01 1.89 [1.60, 2.24] 1.0e-13 1165
5 years 0.00 3.37 [2.95, 3.85] 1.5e-71 654
1 year 0.00 8.94 [7.63, 10.48] <1e-100 341

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: F5_DEPRESSIO – Depression
GWS hits: 8

Survival analyses between endpoints


before Depression
after Depression

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