Mental and behavioural disorders due to opioids

F5_OPIOIDS

opioid dependence: Disorders related or resulting from abuse or mis-use of opioids.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F11
Hospital discharge: ICD-9 3040|3055
Hospital discharge: ICD-8 304[0-1]
Cause of death: ICD-10 F11
Cause of death: ICD-9 3040|3055
Cause of death: ICD-8 304[0-1]

1286

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1075

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Check minimum number of events None

1075

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Include endpoints None

1075

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F5_OPIOIDS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F10-F19
Name in latin Perturbationes mentis et modi se gerendi ex usu opioidum

Summary Statistics

Key figures

All Female Male
Number of individuals 1075 467 608
Unadjusted prevalence (%) 0.30 0.24 0.39
Mean age at first event (years) 35.17 35.23 35.13

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.12 [1.78, 14.74] 2.4e-3 74
15 years 0.02 3.10 [1.35, 7.12] 7.6e-3 29
5 years 0.01 5.75 [2.84, 11.61] 1.1e-6 21
1 year 0.00 19.70 [9.22, 42.10] 1.4e-14 14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: F5_OPIOIDS – Mental and behavioural disorders due to opioids
GWS hits:

Survival analyses between endpoints

Plot

before Mental and behavioural disorders due to opioids
after Mental and behavioural disorders due to opioids

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Drugs most likely to be purchased after Mental and behavioural disorders due to opioids