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Substance abuse

DOID MESH PheWeb

KRA_PSY_SUBSTANCE

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F10-F19
Hospital discharge: ICD-9 29[1-2]|30[3-5]
Hospital discharge: ICD-8 291|30[3-4]
Hospital discharge: excluded ICD-10 F10.0
Hospital discharge: excluded ICD-9 3050A
Cause of death: ICD-10 F10-F19
Cause of death: ICD-9 29[1-2]|30[3-5]
Cause of death: ICD-8 291|30[3-4]

20681

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

20253

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Check minimum number of events None

20253

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Include endpoints

21744

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KRA_PSY_SUBSTANCE

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 21744 7610 14134
Unadjusted prevalence (%) 6.11 3.84 8.98
Mean age at first event (years) 45.01 41.33 47.00

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.39 [3.64, 5.29] 6.5e-54 4116
15 years 0.02 2.73 [2.37, 3.15] 7.1e-43 1575
5 years 0.00 4.78 [4.25, 5.37] <1e-100 929
1 year 0.00 22.63 [19.89, 25.74] <1e-100 906

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: KRA_PSY_SUBSTANCE – Substance abuse
GWS hits:

Survival analyses between endpoints

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Plot

before Substance abuse
after Substance abuse

loading spinner Loading survival analyses plot