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Primary open-angle glaucoma, strict

DOID EFO MESH SNOMED PheWeb

H7_GLAUCOMA_POAG

open-angle glaucoma: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 H40.1
Hospital discharge: ICD-9 3651[A|C|E|X]
Hospital discharge: ICD-8 37510
Hospital discharge: excluded ICD-10 H40.10, H40.12
Cause of death: ICD-10 H40.1
Cause of death: ICD-9 3651[A|C|E|X]
Cause of death: ICD-8 37510
Cause of death: excluded ICD-10 H40.10, H40.12

6785

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6785

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Check minimum number of events None

6785

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Include endpoints None

6785

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H7_GLAUCOMA_POAG

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 H40
Name in latin Glaucoma simplex primarium

Summary Statistics

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Key figures

All Female Male
Number of individuals 6785 3680 3105
Unadjusted prevalence (%) 1.91 1.85 1.97
Mean age at first event (years) 67.65 67.29 68.09

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.75 [1.45, 2.10] 3.8e-9 1077
15 years 0.01 1.10 [0.94, 1.29] 2.2e-1 555
5 years 0.00 1.54 [1.32, 1.80] 7.2e-8 298
1 year 0.00 2.02 [1.56, 2.62] 9.7e-8 74

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_GLAUCOMA_POAG – Primary open-angle glaucoma, strict
GWS hits: 37

Survival analyses between endpoints

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Plot

before Primary open-angle glaucoma, strict
after Primary open-angle glaucoma, strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Primary open-angle glaucoma, strict

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