Disorders of optic nerve and visual pathways

H7_OPTNERVE

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Hospital Discharge: ICD-10 H46-H48
Cause of death: ICD-10 H46-H48

2209

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

2209

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2209

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H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Disorders of optic nerve and visual pathways based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 2445 1603 842
Unadjusted prevalence (%) 0.69 0.81 0.54
Mean age at first event (years) 44.52 42.01 49.29

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.45 [1.71, 3.51] 1.1e-6 197
15 years 0.01 1.24 [0.83, 1.84] 3.0e-1 72
5 years 0.00 2.27 [1.36, 3.79] 1.8e-3 47
1 year 0.00 8.75 [5.17, 14.82] 7.0e-16 33

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_OPTNERVE – Disorders of optic nerve and visual pathways
GWS hits:

Survival analyses between endpoints

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Drugs most likely to be purchased after Disorders of optic nerve and visual pathways