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Disorders of sclera, cornea, iris and ciliary body

DOID EFO MESH SNOMED PheWeb

H7_SCLERACORNEA

corneal neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent corneal stroma. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as trachoma, viral interstitial keratitis, microbial keratoconjunctivitis, and the immune response elicited by corneal transplantation.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 H15-H22, H22.0*B96.80
Cause of death: ICD-10 H15-H22, H22.0*B96.80

16940

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

16940

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Check minimum number of events None

16940

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Include endpoints

17663

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H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 17663 9883 7780
Unadjusted prevalence (%) 4.96 4.98 4.94
Mean age at first event (years) 49.59 48.78 50.62

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.84 [1.48, 2.28] 2.8e-8 1329
15 years 0.01 1.19 [0.97, 1.45] 8.9e-2 599
5 years 0.00 2.38 [2.02, 2.82] 2.9e-24 388
1 year 0.00 3.98 [3.18, 4.98] 1.8e-33 124

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_SCLERACORNEA – Disorders of sclera, cornea, iris and ciliary body
GWS hits: 10

Survival analyses between endpoints

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Plot

before Disorders of sclera, cornea, iris and ciliary body
after Disorders of sclera, cornea, iris and ciliary body

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Drugs most likely to be purchased after Disorders of sclera, cornea, iris and ciliary body

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